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Subsequent mass spectrometry analysis identified interacting proteins, with AFG3-like matrix AAA peptidase subunit 2 (AFG3L2), a mitochondrial inner membrane m-AAA protease, highlighted as a key interactor

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Cancer cells treated with ATN-224 undergo programmed caspase-mediated apoptosis both in vitro and in vivo, indicating that SOD1 may act as a tumor promoter and represents a promising novel target for cancer treatment (Glasauer et al